whoami_

Chris Trethewey · Clinical researcher (haematology + oncology, UK)

email · github · linkedin · orcid · researchgate

// commit activity · last ~4 months
GitHub contribution heatmap

Lymphoma research and open-source bioinformatics, focused on liquid biopsy, molecular profiling, and immune repertoire sequencing.

repos

Sentinel
python · pypi: sentinel-cd
Cross-sample contamination, sample-swap and identity detector for targeted NGS runs.
Lymphix
python · nextflow
BCR / TCR clonality and V(D)J rearrangement calling from custom-panel NGS. TRUST4 + IgBLAST, DNAnexus-ready.
OncoSieve
python · v2.0
Pan-cancer somatic variant curation pipeline. 7 databases · 46.4M variants · 1 curated whitelist.

publications

2026
A phase IIa study of the anti-PD-L1 antibody avelumab in relapsed/refractory PTCL: the AVAIL-T trial British Journal of Haematology · submitted
2026
Phased Variant–Supported Circulating Tumor DNA as a Prognostic Biomarker After First-Line Treatment in Large B-Cell Lymphoma: Findings From the DIRECT Study Journal of Clinical Oncology · DOI 10.1200/JCO-25-01587 · PMID 41428995
2026
Sentinel: Cross-sample contamination, sample-swap and identity detector for targeted NGS runs Zenodo (software) · DOI 10.5281/zenodo.20264481
2025
The DIRECT study: A roadmap for ctDNA-based risk prediction, molecular profiling and MRD detection in Diffuse Large B Cell Lymphoma medRxiv (preprint) · DOI 10.1101/2025.04.14.25325806
2024
Monitoring of molecular responses to tirabrutinib in a cohort of exceptional responders with relapsed/refractory mantle cell lymphoma eJHaem · DOI 10.1002/jha2.966 · PMID 39157626
2023
BTK mutations in patients with chronic lymphocytic leukemia receiving tirabrutinib Blood Advances · DOI 10.1182/bloodadvances.2022009366 · PMID 37257190
2023
Molecular Profiling of Circulating Tumour DNA in Aggressive Lymphoid Malignancies Thesis · DOI 10.25392/leicester.data.23966973.v1
2022
Limitations of Monitoring Disease Progression Using Circulating Tumor DNA in Lymphoma: An Example From Primary Cutaneous DLBCL Leg-type HemaSphere · DOI 10.1097/HS9.0000000000000690 · PMID 35261967
2020
Multiple mutations at exon 2 of RHOA detected in plasma from patients with peripheral T-cell lymphoma Blood Advances · DOI 10.1182/bloodadvances.2019001075 · PMID 32484856
2019
Successful Treatment of Primary Cutaneous Diffuse Large B-Cell Lymphoma Leg Type With Single-Agent Venetoclax JCO Precision Oncology · DOI 10.1200/PO.19.00002 · PMID 35100690
2019
Circulating tumour DNA analysis to detect clonal evolution in TP53 mutated CLL treated with sequential precision medicines British Journal of Haematology · BSH 2019 abstract (BSH19-PO-096) · DOI 10.1111/bjh.15854
2019
Successful treatment of primary cutaneous diffuse large B cell lymphoma leg type with single agent venetoclax British Journal of Haematology · BSH 2019 abstract (BSH19-EP-024) · DOI 10.1111/bjh.15854
2019
Studying the molecular mechanisms of resistance to the irreversible, covalent BTK inhibitor, Tirabrutinib British Journal of Haematology · BSH 2019 abstract · DOI 10.1111/bjh.15854